Its use in the treatment of malaria, quinine sulfate is sometimes used off-label for the treatment of nocturnal leg cramps, but its effectiveness for this condition is controversial. Quinine sulfate can cause side effects such as nausea, vomiting, diarrhea, headache, tinnitus (ringing in the ears), and vision disturbances, and in rare cases can cause serious adverse effects such as cardiac arrhythmias and allergic reactions. Therefore, it should only be used under the supervision of a healthcare professional.
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